How should ibuprofen (Motrin®) be administered to prevent gastrointestinal upset?

Administering ibuprofen with food is advisable to minimize gastrointestinal upset. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can irritate the stomach lining and increase the risk of gastrointestinal bleeding or ulcers, especially when taken on an empty stomach. Consuming ibuprofen with food can help buffer the stomach and reduce acidity, making the medication easier on the digestive system.

While drinking a glass of water or milk may also provide some comfort, they do not specifically address the potential irritation that ibuprofen can cause. Food serves to create a protective layer in the stomach, which is particularly beneficial for individuals who may be more susceptible to these side effects. Thus, taking ibuprofen with food is a recommended practice to enhance safety and reduce gastrointestinal discomfort.